What is mNetAlign  
mNetAlign is a web-interfaced database designed to facilitate the comparison of protein interaction networks (PINs) across multiple species. Its goal is to identify conserved networks substructures (CoNSs) that are conserved across species. The core of mNetAlign is NetAlign [1,2], which enables pairwise PIN comparison, and the following clustering. In mNetAlign, the CoNSs (c-CoNSs; clustered CoNSs) shared by several PINs can be identified through multi-species clustering on the pre-computed genome-scale pairwise PIN comparisons.
mNetAlign supports comparison among the seven largest PINs currently available of E. coli, H. pylori, S. cerevisiae, C. elegans, D. melanogaster, M. musclus and H. sapiens. The identifeid CoNSs may derive from a common ancestor and disclose conserved topological organization of interactions in evolution Besides, mNetAlign will report enrichment of GO annotations within the identified CoNSs, which faciliates the analysis and inference of their potential biological functions.

References
(1) Liang, Z., Xu, M., Teng, M. and Niu, L. (2006) NetAlign: a web-based tool for comparison of protein interaction networks. Bioinformatics, 22, 2175-2177.
(2) Liang, Z., Xu, M., Teng, M. and Niu, L. (2006) Comparison of protein interaction networks reveals species conservation and divergence. BMC Bioinformatics, 7, 457.
How to use mNetAlign
It is very easy to use mNetAlign. First, specify the PINs to compare by checking the corresponding species at the following. Second and optionally, specify a GO level value (the first level are the three basic GO terms: biological process, cellular component and molecular function; the default GO level is 4). Enrichment of invovled GO annotations within the identified c-CoNSs will be reported if they are at or under the specified level in the GO hierarchy.


:: Species list ::
E.coli H.pylori S.cerevisiae C.elegans D.melanogaster M.musclus H.sapiens
:: GO level ::
Note:
We use the following abbreviations for species names in the report: Ecoli - E. coli, Hpylo - H. pylori, Scere - S. cerevisiae, Celeg - C. elegans, Dmela - D. melanogaster, Mmusc - M. musclus, Hsapi - H. sapiens
     

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